It also seems unfortunate coming from Anita, who as a woman (though who knows, really? Beyond loud proclamations?) also has a lot of estrogen. In fact, if she were alone in the room, it would still be "estrogen rich."

On the pragmatic side, until they hit puberty girls have a minimal amount of estrogen in their systems. It doesn't make sense in that respect for boys to "not count as male" but for girls to count as "female" if the deciding gender factor is age. Little girls are just as "generic" at that age.